Cayman N-Arachidonyl Maleimide; Purity- Greater Than Or Equal To

2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the central cannabinoid (CB₁) and peripheral cannabinoid (CB₂) receptors.^,, 2-AG is present at relatively high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol found in rat brain.^, Monoacylglycerol lipase (MGL) hydrolyzes 2-AG to arachidonic acid and glycerol, thereby terminating its biological actions. N-Arachidonyl maleimide (NAM) is a potent, irreversible inhibitor of monoacylglycerol lipase (MGL) or MGL-like activity in rat cerebellar membranes, exhibiting an IC₅₀ value of 140 nM. Inhibition of MGL by the sulfhydryl-reactive maleimide group of NAM suggests a critical cysteine residue is present in the substrate-binding site of the enzyme.

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