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Cayman Fk-506; Purity- Greater Than Or Equal To 99%; Size- 10 Mg
Cayman Fk-506; Purity- Greater Than Or Equal To 99%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$66.00
Your Price
$66.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-10007965-10 |
| MFG.PART: | 10007965-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
FK-506 is a potent immunosuppressant in the same molecular class as cyclosporin A (Item No. ) and rapamycin (Item No. ). Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). This complex then inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T cell activation. The physiological effects of FK-506 also include regulation of nitric oxide neurotoxicity, neurotransmitter release, and regulation of Ca2+ release via the ryanodine and inositol-(1,4,5)-trisphosphate (IP3) receptors. In the latter case, FKBP12 forms a tight complex with both ryanodine and IP3 receptors which can be disrupted by FK-506, thereby rendering the receptors leaky to Ca2+.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
CAS Number
104987-11-3
Synonyms
- Tacrolimus
Molecular Formula
C44H69NO12
Formula Weight
804.0
Purity
≥99%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 30 mg/ml
- Ethanol:PBS (pH 7.2)(1:5): .15 mg/ml
SMILES
O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]3CC=C)=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)[C@H](C)[C@@H](O)CC3=O
InChi Code
InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1
InChi Key
QJJXYPPXXYFBGM-LFZNUXCKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10007965-10 |
|---|---|
| Supplier Part Number | 10007965-10 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/10007965m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CN |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | Y |
| CAS Number | 104987-11-3 |