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Cayman Oleic Acid Ethyl Ester; Purity- Greater Than 98%; Size- 50
NETA PART: | CAYM-10008201-50 |
MFG.PART: | 10008201-50 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Endomorphin 1 is an endogenous neuropeptide and μ-opioid receptor agonist (Ki = 0.36 nM) that has analgesic, positive reinforcing, and gastrointestinal properties., It is found in the brain and, to a lesser extent, in the spinal cord. It is selective for μ- over δ- and κ-opioid receptors (Ki = 1,506 and 5,428 nM, respectively). Endomorphin 1 also binds to mouse brain membranes and rat recombinant μ-opioid receptors expressed in CHO cells (Kis = 0.94 and 0.66 nM, respectively). It inhibits cAMP accumulation induced by forskolin in CHO cells expressing rat recombinant μ-opioid receptors and in SH-SY5Y human neuroblastoma cells (IC50s = 9.33 and 19.1 nM, respectively). In mice, endomorphin 1 increases analgesia in a radiant heat tail-flick assay following intracerebroventricular or intrathecal administration (ED50s = 4.75 and 0.726 μg, respectively) and induces conditioned place preference when administered intracerebroventricularly at a dose of 10 μg., Endomorphin 1 (12 μg, i.c.v.) also decreases gastrointestinal transit time in mice.
WARNING This product is not for human or veterinary use.
Technical Information
- Tyr-Pro-Trp-Phe-NH2
- Formic Acid: 1 mg/ml
Shipping & Storage Information
SKU | CAYM-10008201-50 |
---|---|
Supplier Part Number | 10008201-50 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10008201m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 50 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 111-62-6 |