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Cayman 11 Betaprostaglandin F2 Alphad4; Purity- Greater Than
NETA PART: | CAYM-10008989-100 |
MFG.PART: | 10008989-100 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
11β-Prostaglandin F2α-d4 (11β-PGF2α-d4) is intended for use as an internal standard for the quantification of 11β-PGF2α (Item No. ) by GC- or LC-MS. 11β-PGF2α is the primary metabolite of PGD2 (Item No. ). It is formed from PGD2 via the NADPH-dependent aldo-keto reductase PGF synthase (PGFS; Item No. ) in the liver or lung. 11β-PGF2α induces contraction of isolated cat iris sphincter, which endogenously expresses high levels of PGF2α (FP) receptors, with an EC50 value of 0.045 µM. It also induces contraction of isolated human bronchial smooth muscle when used at concentrations ranging from 0.1 to 30 µM. 11β-PGF2α (0.1 and 1 µM) induces phosphorylation of ERK and CREB, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor when used at concentrations of 0.1 and 1 µM.
WARNING This product is not for human or veterinary use.
Technical Information
- 9α,11β-
PGF2α- d4 - 11β-
PGF2α- d4 - 11-
epi PGF2α- d4
- Ethanol: 100 mg/ml
- DMF: 100 mg/ml
- DMSO: 100 mg/ml
- PBS (pH 7.2): 10 mg/ml
Shipping & Storage Information
SKU | CAYM-10008989-100 |
---|---|
Supplier Part Number | 10008989-100 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10008989m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 100 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 1240398-18-8 |