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Cayman Ly223982; Purity- Greater Than Or Equal To 98%; Size- 5 Mg
NETA PART: | CAYM-10010024-5 |
MFG.PART: | 10010024-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Methysergide is an agonist of the serotonin (5-HT) receptor subtype 5-HT1 and an antagonist of 5-HT2 receptors., It binds to recombinant human 5-HT1A (KD = 23.44 nM), 5-HT1E (Ki = 229.09 nM), 5-HT1F (Ki = 33.88 nM), and rodent 5-HT1B receptors (KD = 1,513.56 nM). It also binds to recombinant human 5-HT2A (Ki = 2.69 nM) and 5-HT2C receptors (KD = 1.26 nM) and is an insurmountable antagonist at 5-HT2B receptors. It inhibits vasoconstriction induced by 5-HT (Item No. ) in isolated postmortem human basilar arterial spiral strips (pA2 = 8.07). Methysergide decreases external carotid blood flow in a dose-dependent manner in vagosympathectomized dogs, an effect that is inhibited by the 5-HT1B/1D receptor antagonist GR127935 (Item No. ). It has antinociceptive activity in mouse models of pain induced by intrathecal injection of substance P (Item No. ), glutamate, NMDA (Item No. ), AMPA (Item No. ), or kainic acid. Methysergide reduces zymosan-induced paw edema in rats when administered at a dose of 10 mg/kg. Formulations containing methysergide were previously used in the prevention and treatment of vascular headaches.
WARNING This product is not for human or veterinary use.
Technical Information
- Desernil
- NSC 186061
- DMSO: slightly soluble
- Methanol: slightly soluble
Shipping & Storage Information
SKU | CAYM-10010024-5 |
---|---|
Supplier Part Number | 10010024-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10010024m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 117423-74-2 |