Cayman 17-Trifluoromethylphenyl Trinor Prostaglandin F2 Alpha Iso

iHAP1 is an inhibitor of tubulin polymerization (IC₅₀ = 0.87 µM in a cell-free assay) that was originally identified as an activator of a heterotrimeric protein phosphatase 2A (PP2A) complex containing the PP2A-B56ε regulatory B subunit in a study that has since been retracted.^,, It does not bind to protein phosphatase 2 regulatory subunit 1A (PPP2R1A) when used at a concentration of 20 µM nor activate PP2A-B55α, PP2A-B56α, or PP2A-B56ε in a cell-free dephosphorylation assay at 10 µM. iHAP1 inhibits the proliferation of K562 leukemia cells (IC₅₀ = 0.84 µM) and induces apoptosis in HeLa cells when used at a concentration of 0.5 µM.^, iHAP1 also inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC₅₀ values of 5.9 and 5.3 µM, respectively.

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