Cayman Cox-2 (Mouse) Polyclonal Fitc Antibody; Size- 1 Ea

Apicidin is a cyclic tetrapeptide that has been found in F. pallidoroseum and has diverse biological activities.^,,, It is active against E. tenella, T. gondii, P. falciparum, C. parvum, N. caninum, B. jellisoni, and C. bigenetica (MICs = 62, 8, 125, 30, 15, 4, and 8 ng/ml, respectively) and decreases the percentage of P. berghei-infected erythrocytes in a mouse model of malaria when administered at a dose of 25 mg/kg. Apicidin inhibits histone deacetylase (HDAC) activity in E. tenella homogenates (IC₅₀ = 0.7 nM) and recombinant human HDAC2 and HDAC3 (EC₅₀s = 120 and 43 nM, respectively).^, It inhibits the proliferation of SKOV3 ovarian cancer cells (EC₅₀ = 1-2.5 µM) and induces cell cycle arrest at the G₀/G₁ phase in SKOV3 cells when used at a concentration of 50 nM. Apicidin (3.5 mg/kg every two days, i.p.) prevents decreases in freezing time in contextual fear conditioning tests, indicating a reversal of memory deficits, and accumulation of amyloid-β (1-40) (Αβ40) and Αβ42 in the hippocampus and cortex in an APPswe/PSEN1dE9 transgenic mouse model of Alzheimers disease.

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