Cayman 16-Phenoxy Tetranor Prostaglandin F2 Alpha Isopropyl Ester

The hepatocyte growth factor receptor c-Met commonly shows elevated activity in several forms of cancer.^, SGX523 is a potent, selective, ATP-competitive inhibitor that blocks the tyrosine kinase activity of c-Met with an IC₅₀ value of 4 nM. It is over 1,000-fold selective for c-Met over a panel of other kinases. SGX523 is orally active and dose-dependently inhibits the growth of a variety of tumor xenografts in mice.^, The effectiveness of SGX523 is enhanced when combined with other chemotherapeutic compounds, including inhibitors of EGFR.^, SGX523 is metabolized, at least in part, by aldehyde oxidase, an enzyme that differs in activity across different species.

WARNING This product is not for human or veterinary use.