Cayman Prostaglandin D2-D9; Purity- Greater Than Or Equal To 99%

Prostaglandin D₂-d₉ (PGD₂-d₉) is intended for use as an internal standard for the quantification of PGD₂ (Item No. 12010) by GC- or LC-MS. PGD₂ is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.¹ Mastocytosis patients produce excessive amounts of PGD₂, which causes vasodilation, flushing, hypotension, and syncopal episodes.¹ PGD₂ is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace.^2,3 In the brain, PGD₂ produces normal physiological sleep and lowering of body temperature.^2,3 Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.⁴ PGD₂ inhibits human ovarian tumor cell proliferation with an IC₅₀ value of 6.8 µM.⁵

WARNING This product is not for human or veterinary use.