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Cayman Erbstatin Analog; Purity- Greater Than Or Equal To 98%; Si
Cayman Erbstatin Analog; Purity- Greater Than Or Equal To 98%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$14.00
Your Price
$14.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-10010238-1 |
| MFG.PART: | 10010238-1 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
PTC-596 is an inhibitor of B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), which is a member of the polycomb repressive complex 1 (PRC1) that has a role in gene silencing., It inhibits proliferation of MOLM-13 acute myeloid leukemia (AML) and Rec-1 mantle cell lymphoma (MCL) cancer cells (IC50s = 22.4 and 136 nM, respectively). It also induces BMI1 degradation in, and apoptosis of, the same cells. PTC-596 reduces microtubule polymerization and induces cell cycle arrest at the G2/M phase in MM.1S multiple myeloma cells. It decreases the number of side population cells, a unique cell population with stem-like characteristics, in Rec-1 cells (IC50 = 138 nM). PTC-596 (5 mg/kg, p.o.) increases survival in a MOLM-13 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-fluoro-2-
CAS Number
1610964-64-1
Synonyms
- Unesbulin
Molecular Formula
C19H13F5N6
Formula Weight
420.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 5 mg/ml
λmax
222, 262, 300 nm
SMILES
FC1=CC2=C(N=C(C)N2C3=NC(NC4=CC=C(C(F)(F)F)C=C4)=C(F)C(N)=N3)C=C1
InChi Code
InChI=1S/C19H13F5N6/c1-9-26-13-7-4-11(20)8-14(13)30(9)18-28-16(25)15(21)17(29-18)27-12-5-2-10(3-6-12)19(22,23)24/h2-8H,1H3,(H3,25,27,28,29)
InChi Key
TWLWOOPCEXYVBE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10010238-1 |
|---|---|
| Supplier Part Number | 10010238-1 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/10010238m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | Y |
| CAS Number | 63177-57-1 |