Cayman Erbstatin Analog; Purity- Greater Than Or Equal To 98%; Si

Product Description

Overactivity of the epidermal growth factor (EGF) receptor-associated tyrosine kinase has been associated with a number of cancers and thus tyrosine kinase inhibitors could be potential therapeutic agents to prevent malignant growth.¹ Erbstatin is a potent, small-molecule inhibitor of EGF receptor-associated tyrosine kinase. However, it is highly unstable, inactivating completely within 30 minutes in calf serum.² Erbstatin analog is a stable, potent inhibitor of EGFR kinase activity. It is four-times more stable than erbstatin in calf serum² and inhibits EGFR tyrosine kinase in vitro similar to erbstatin with an IC₅₀ value of 0.14 µg/ml.² Erbstatin analog inhibits EGF-stimulated growth in EGFR-overexpressing NIH3T3 cells with an IC₅₀ value of 0.5 µg/ml and efficiently delays the onset of EGF-induced DNA synthesis.³

WARNING This product is not for human or veterinary use.

Technical Information