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Cayman Ag-494; Purity- Greater Than Or Equal To 98%; Size- 10 Mg
Cayman Ag-494; Purity- Greater Than Or Equal To 98%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$64.00
Your Price
$64.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-10010242-10 |
| MFG.PART: | 10010242-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
CAY10735 is an anticancer compound. It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mesenchymal transition (EMT) in A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10735 (5 mg/kg) reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | N-[2-[[[1-[[(4-fluorophenyl)amino]carbonyl]cyclopropyl]carbonyl]amino]ethyl]-2-methylene-3-oxo-olean-12-en-28-amide |
| CAS Number | 2251753-58-7 |
| Molecular Formula | C44H60FN3O4 |
| Formula Weight | 714.0 |
| Purity | ≥90% |
| Formulation | A crystalline solid |
| Solubility |
|
| λmax | 243 nm |
| SMILES | C=C1C(C(C)(C)[C@@](CC[C@]2(C)[C@]3([H])CC=C4[C@@]2(C)CC[C@]5(C(NCCNC(C6(CC6)C(NC7=CC=C(F)C=C7)=O)=O)=O)[C@@]4([H])CC(C)(C)CC5)([H])[C@]3(C)C1)=O |
| InChi Code | InChI=1S/C44H60FN3O4/c1-27-25-40(6)32(39(4,5)34(27)49)15-16-42(8)33(40)14-13-30-31-26-38(2,3)17-19-43(31,20-18-41(30,42)7)35(50)46-23-24-47-36(51)44(21-22-44)37(52)48-29-11-9-28(45)10-12-29/h9-13,31-33H,1,14-26H2,2-8H3,(H,46,50)(H,47,51)(H,48,52)/t31-,32-,33+,40-,41+,42+,43-/m0/s1 |
| InChi Key | QGKCNAYWPGAXOU-LBWRYPOYSA-N |
| Storage | -20°C |
| Shipping | Wet ice in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-10010242-10 |
|---|---|
| Supplier Part Number | 10010242-10 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/10010242m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | Y |
| CAS Number | 133550-35-3 |