We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Share this :
Print
Cayman Stearic Acid; Purity- Greater Than Or Equal To 98%; Size-
Cayman Stearic Acid; Purity- Greater Than Or Equal To 98%; Size- 1 G; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$17.00
Your Price
$17.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-10011298-1000 |
| MFG.PART: | 10011298-1000 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
SKL2001 is an activator of Wnt/β-catenin signaling., It increases β-catenin responsive transcription in a cell-based reporter assay in a concentration-dependent manner, increases β-catenin protein levels in HEK293 cells when used at concentrations of 10 and 30 μM, and disrupts the interaction between Axin and β-catenin. SKL2001 increases alkaline phosphatase (ALP) activity and mineralization in multipotent mesenchymal ST2 cells in a concentration-dependent manner, indicating increased osteoblastogenesis. SKL2001 (40 μM) reduces HCT116 and HT-29 spheroid growth and inhibits proliferation of HCT116 and HT-29 cells. It induces cell cycle arrest at the G0/G1 phase and increases E-cadherin and β-catenin protein levels in HCT116 cells when used at a concentration of 40 μM.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-(2-
CAS Number
909089-13-0
Synonyms
- Wnt Agonist II
Molecular Formula
C14H14N4O3
Formula Weight
286.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 25 mg/ml
- DMSO: 25 mg/ml
- Ethanol: 25 mg/ml
- Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
247, 288 nm
SMILES
O=C(NCCCN1C=CN=C1)C2=NOC(C3=CC=CO3)=C2
InChi Code
InChI=1S/C14H14N4O3/c19-14(16-4-2-6-18-7-5-15-10-18)11-9-13(21-17-11)12-3-1-8-20-12/h1,3,5,7-10H,2,4,6H2,(H,16,19)
InChi Key
PQXINDBPUDNMPE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10011298-1000 |
|---|---|
| Supplier Part Number | 10011298-1000 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/10011298m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 1000 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | Y |
| CAS Number | 57-11-4 |