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Cayman Stearic Acid; Purity- Greater Than Or Equal To 98%; Size-
Cayman Stearic Acid; Purity- Greater Than Or Equal To 98%; Size- 5 G; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$40.00
Your Price
$40.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-10011298-5000 |
MFG.PART: | 10011298-5000 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
TP-3654 is an inhibitor of Pim kinases (Kis = 5, 239, and 42 nM for Pim-1, Pim-2, and Pim-3, respectively). It inhibits 19 additional kinases, including PI3Kα, PI3Kγ, and PI3Kδ, with IC50 values of less than 300 nM. TP-3654 inhibits phosphorylation of Bad in HEK293 cells overexpressing Bad and Pim-1 (EC50 = 67 nM), as well as in UM-UC-3 cells. It reduces tumor growth in UM-UC-3 bladder carcinoma and PC3 prostate adenocarcinoma mouse xenograft models when administered at a dose of 200 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
trans-α,α- dimethyl-4- [[3-[3- (trifluoro methyl) phenyl] imidazo [1,2-b] pyridazin-6- yl]amino]- cyclohexane methanol
CAS Number
1361951-15-6
Molecular Formula
C22H25F3N4O
Formula Weight
418.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 16 mg/ml
- DMSO: 16 mg/ml
- DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
- Ethanol: 10 mg/ml
λmax
217, 274, 342 nm
SMILES
CC(C)(O)[C@H]1CC[C@H](NC2=NN3C(C=C2)=NC=C3C4=CC=CC(C(F)(F)F)=C4)CC1
InChi Code
InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)/t15-,17-
InChi Key
XRNVABDYQLHODA-JCNLHEQBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-10011298-5000 |
---|---|
Supplier Part Number | 10011298-5000 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10011298m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5000 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 57-11-4 |