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Cayman Al 34662; Purity- Greater Than Or Equal To 98%; Size- 1 Mg
NETA PART: | CAYM-10011546-1 |
MFG.PART: | 10011546-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
PTC-596 is an inhibitor of B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), which is a member of the polycomb repressive complex 1 (PRC1) that has a role in gene silencing., It inhibits proliferation of MOLM-13 acute myeloid leukemia (AML) and Rec-1 mantle cell lymphoma (MCL) cancer cells (IC50s = 22.4 and 136 nM, respectively). It also induces BMI1 degradation in, and apoptosis of, the same cells. PTC-596 reduces microtubule polymerization and induces cell cycle arrest at the G2/M phase in MM.1S multiple myeloma cells. It decreases the number of side population cells, a unique cell population with stem-like characteristics, in Rec-1 cells (IC50 = 138 nM). PTC-596 (5 mg/kg, p.o.) increases survival in a MOLM-13 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
- Unesbulin
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 5 mg/ml
Shipping & Storage Information
SKU | CAYM-10011546-1 |
---|---|
Supplier Part Number | 10011546-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10011546m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 210580-75-9 |