Cayman 15(R)-Iloprost; Purity- Greater Than Or Equal To 97%; Size

The peptide hormone gastrin acts through G protein-coupled cholecystokinin-2 (CCK₂) receptors to regulate cell proliferation, differentiation, apoptosis, and gene expression of gastrointestinal cells and exerts trophic effects on a number of gastric cancer cell lines. AG-041R is a potent gastrin/CCK₂ receptor antagonist that exhibits selective binding for CCK₂ compared to CCK₁. AG-041R inhibits gastrin-evoked secretion of pancreastatin (IC₅₀ = 2.2 nM) as well as gastrin-induced histamine release and cell growth of Mastomys ECL carcinoid tumor cells.^, AG-041R (1 µM) exhibits synergistic inhibitory effects on the cell viability of human gastric cancer cells when administered in combination with the selective COX-2 inhibitor NS-398 (Item No. ) at 10 µM.

WARNING This product is not for human or veterinary use.