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Cayman 15(R)-Iloprost; Purity- Greater Than Or Equal To 97%; Size
NETA PART: | CAYM-10043-10 |
MFG.PART: | 10043-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Ixabepilone is an epothilone with broad-spectrum anticancer activity against a panel of 21 cancer cell lines (IC50s = 1.4-34.5 nM). It stabilizes and induces the polymerization of microtubules and induces cell cycle arrest during mitosis. Ixabepilone is cytotoxic to HCT116/VM46 and A2780Tax clonogenic cells, which are resistant to paclitaxel (Item No. ; IC90s = 16 and 12.3 nM, respectively, for colony growth inhibition). In vivo, ixabepilone (6.3 and 10 mg/kg, i.v., respectively) shows antitumor activity in paclitaxel-resistant human Pat-21 breast carcinoma and HCT116/VM46 colon carcinoma mouse xenograft models with log cell kill (LCK) values of 1.6 and 2.4, respectively. Ixabepilone (10 mg/kg, i.v.) also increases the time for tumors to quadruple in volume by 7.2, 9, 6.5, 4.7, and >10 weeks, respectively, in mice implanted with Rh18 rhabdomyosarcoma, NB1643 neuroblastoma, WT5 Wilms tumor, OS29 osteosarcoma, and BT29 brain carcinoma cells. Formulations containing ixabepilone have used in the treatment of metastatic breast cancer.
WARNING This product is not for human or veterinary use.
Technical Information
- Azaepothilone B
- BMS-247550
- DMF: 20 mg/ml
- DMSO: 15 mg/ml
- Ethanol: 20 mg/ml
- Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
Shipping & Storage Information
SKU | CAYM-10043-10 |
---|---|
Supplier Part Number | 10043-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10043m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 85026-51-3 |