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Cayman Sc-57461a; Purity- Greater Than Or Equal To 98%; Size- 1 M
Cayman Sc-57461a; Purity- Greater Than Or Equal To 98%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$32.00
Your Price
$32.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-10108-1 |
| MFG.PART: | 10108-1 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 (Item No. ) from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro., SC-57461A is a potent, orally active inhibitor of LTA4 hydrolase that blocks ionophore-stimulated LTB4 synthesis in whole blood (IC50 = 49 nM)., It blocks both the hydrolase and aminopeptidase activity in vitro. SC-57461A is without effect against other enzymes of the arachidonic acid cascade, including 5-lipoxygenase, LTC4 synthase, COX-1, and COX-2. In a rat model of ionophore-induced peritoneal eicosanoid production, SC-57461A inhibits LTB4 biosynthesis without affecting LTC4 (Item No. ) or 6-keto prostaglandin F1α production (Item No. ). Oral or topical pretreatment with SC-57461A before challenge with arachidonic acid blocks ear edema in mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-methyl-
CAS Number
423169-68-0
Molecular Formula
C20H25NO3 • HCl
Formula Weight
363.9
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 3 mg/ml
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
- DMSO: 3 mg/ml
- Ethanol: 0.25 mg/ml
λmax
266, 277 nm
SMILES
CN(CCC(O)=O)CCCOC(C=C1)=CC=C1CC2=CC=CC=C2.Cl
InChi Code
InChI=1S/C20H25NO3.ClH/c1-21(14-12-20(22)23)13-5-15-24-19-10-8-18(9-11-19)16-17-6-3-2-4-7-17;/h2-4,6-11H,5,12-16H2,1H3,(H,22,23);1H
InChi Key
SBBJJLDNKNNWFJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10108-1 |
|---|---|
| Supplier Part Number | 10108-1 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/10108m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | GB |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 423169-68-0 |