We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Sc-57461a; Purity- Greater Than Or Equal To 98%; Size- 25
NETA PART: | CAYM-10108-25 |
MFG.PART: | 10108-25 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 (Item No. 20110) from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro.1,2 SC-57461A is a potent, orally active inhibitor of LTA4 hydrolase that blocks ionophore-stimulated LTB4 synthesis in whole blood (IC50 = 49 nM).3,4 It blocks both the hydrolase and aminopeptidase activity in vitro.4 SC-57461A is without effect against other enzymes of the arachidonic acid cascade, including 5-lipoxygenase, LTC4 synthase, COX-1, and COX-2. In a rat model of ionophore-induced peritoneal eicosanoid production, SC-57461A inhibits LTB4 biosynthesis without affecting LTC4 (Item No. 20210) or 6-keto prostaglandin F1α production (Item No. 15210).5 Oral or topical pretreatment with SC-57461A before challenge with arachidonic acid blocks ear edema in mice.5
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 3 mg/ml
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
- DMSO: 3 mg/ml
- Ethanol: 0.25 mg/ml
Shipping & Storage Information
SKU | CAYM-10108-25 |
---|---|
Supplier Part Number | 10108-25 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10108m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | GB |
ProductLine | CAYM |
Qty | 25 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 423169-68-0 |