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Cayman Sc-57461a; Purity- Greater Than Or Equal To 98%; Size- 5 M
Cayman Sc-57461a; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$109.00
Your Price
$109.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-10108-5 |
| MFG.PART: | 10108-5 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
COTI-2 is an orally available thiosemicarbazone that activates mutant forms of p53. It induces apoptosis in a wide variety of human tumor cells in culture, inhibits the proliferation of colorectal cancer cell lines more effectively than cetuximab and erlotinib (Item No. ), and is active against human glioblastoma cell lines at nanomolar concentrations. COTI-2 functions well in vivo, inhibiting the growth of HT-29 colorectal, SHP-77 small cell lung cancer, and OVCAR-3 ovarian carcinoma xenograft cells in mice with minimal toxicity.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-(2-
CAS Number
1039455-84-9
Molecular Formula
C19H22N6S
Formula Weight
366.5
Purity
≥95% (E/Z mixture)
Formulation
A crystalline solid
Solubility
- DMF: 2.5 mg/mL
- DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL
- DMSO: 1 mg/mL
SMILES
S=C(N/N=C1C(N=CC=C2)=C2CCC\1)N(CC3)CCN3C4=NC=CC=C4
InChi Code
InChI=1S/C19H22N6S/c26-19(23-22-16-7-3-5-15-6-4-10-21-18(15)16)25-13-11-24(12-14-25)17-8-1-2-9-20-17/h1-2,4,6,8-10H,3,5,7,11-14H2,(H,23,26)/b22-16-
InChi Key
UTDAKQMBNSHJJB-JWGURIENSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-10108-5 |
|---|---|
| Supplier Part Number | 10108-5 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/10108m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | GB |
| ProductLine | CAYM |
| Qty | 5 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 423169-68-0 |