Cayman D-Erythro-Mapp; Purity- Greater Than Or Equal To 98%; Size

Cayman D-Erythro-Mapp; Purity- Greater Than Or Equal To 98%; Size- 500 Micrograms; - CAYM (Additional S&H Or Hazmat Fees May Apply)

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NETA PART:	CAYM-10165-500
MFG.PART:	10165-500
UNSPSC:	12352200
Manufacturer:	Cayman

Description

Product Description

D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (K_i = 2-13 µM; IC₅₀ = 1-5 µM).¹ It is selective for alkaline ceramidase over acid ceramidase (IC₅₀ = >500 µM) as well as the serine/threonine protein phosphatase CAPP at concentrations up to 10 µM. D-erythro-MAPP increases intracellular ceramide levels, induces cell cycle arrest at the G₀/G₁ phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner.

WARNING This product is not for human or veterinary use.

Technical Information

Formal Name

N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrien-1-yl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2E,4E,6R-trimethyl-2,4-decadienamide

CAS Number

143492-38-0

Synonyms

(1S,2R-D-erythro-2-N-myristoylamino)-1-phenyl-1-propanol

Molecular Formula

C₂₃H₃₉NO₂

Formula Weight

361.6

Purity

≥98%

Formulation(Request formulation change)

A crystalline solid

Solubility(Learn about Variance in Solubility)

DMF: 20 mg/ml
DMSO: .1 mg/ml
Ethanol: 20 mg/ml
Ethanol:PBS (pH 7.2) (1:2): .5 mg/ml

SMILES

O[C@H]([C@H](N(C(CCCCCCCCCCCCC)=O)[H])C)C1=CC=CC=C1

InChi Code

InChI=1S/C23H39NO2/c1-3-4-5-6-7-8-9-10-11-12-16-19-22(25)24-20(2)23(26)21-17-14-13-15-18-21/h13-15,17-18,20,23,26H,3-12,16,19H2,1-2H3,(H,24,25)/t20-,23-/m1/s1

InChi Key

YLAZEWZHIRBZDA-NFBKMPQASA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room Temperature in continental US; may vary elsewhere

Stability

≥ 4 years

Specifications

More Information
SKU	CAYM-10165-500
Supplier Part Number	10165-500
UM	UNIT
UNSPSC	12352200
Manufacturer	Cayman
MSDS URL	https://www.caymanchem.com/msdss/10165m.pdf
Temperature	-20
Refrigerated-Frozen	Refrigerated
CountryOfOrigin	US
ProductLine	CAYM
Qty	500
MinOrderQty	1
Weight	7.00
Lead Time	2 Business Days
Hazardous	N
CAS Number	143492-38-0

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Cayman D-Erythro-Mapp; Purity- Greater Than Or Equal To 98%; Size

Product Description

Technical Information

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