Cayman 11 Betahydroxysteroid Dehydrogenase (Type 2) Blocking Pe

11-Hydroxysteroid dehydrogenase type 2 (11β-HSD2) plays a critical role in normal physiology in the corticosteroid regulation of sodium homeostasis and the pathophysiology of hypertension by converting active cortisol to inactive cortisone. Mutation in the gene encoding 11β-HSD2 results in cortisol induction of hypertension and hypokalemia, a syndrome of apparent mineralocorticoid excess. Expression of 11β-HSD2 mRNA and protein has been shown in placenta and mineralocorticoid target tissues, particularly the kidney. In mouse, expression of this enzyme is tissue- and developmentally specific, indicating the importance of the enzyme in regulating glucocorticoid-mediated maturation. Cayman’s 11β-HSD2 polyclonal antibody detects a band at around 44 kDa in tissues such as kidney and cell lines including Caco-2 cells and HT-29 cells.

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