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Cayman (S)-Am1241; Purity- Greater Than Or Equal To 98%; Size- 10
NETA PART: | CAYM-10490-10 |
MFG.PART: | 10490-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development.,, UNC0224 is a potent and selective G9a HMTase inhibitor, exhibiting an IC50 value of 15 nM. Isothermal titration calorimetry revealed UNC0224 binds to G9a with a Kd value of 29 nM. UNC0224 also inhibits GLP, a closely-related H3K9 HMTase, with assay-dependent IC50 values of 20-58 nM, but is more than 1,000-fold selective against SET7/9 (a H3K4 HMTase) and SET8 (a H4K20 HMTase).
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 2.5 mg/ml
- DMSO: 2 mg/ml
- Ethanol: 15 mg/ml
- PBS (pH 7.2): 2.5 mg/ml
Shipping & Storage Information
SKU | CAYM-10490-10 |
---|---|
Supplier Part Number | 10490-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10490m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 444912-53-2 |