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Cayman Sulforaphane; Purity- Greater Than Or Equal To 98%; Size-
Cayman Sulforaphane; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$41.00
Your Price
$41.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-10496-5 |
| MFG.PART: | 10496-5 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Ambrisentan is a nonpeptide endothelin A (ETA) receptor antagonist (IC50s = 0.251, 0.316, 0.398, 251, and 630 nM for rat preparations of heart, bladder, kidney, lung, and cerebral cortex, respectively). It inhibits contraction of isolated rabbit aortic rings induced by endothelin-1 (ET-1; Item No. ) by 43.23% when used at a concentration of 1 µM. Ambrisentan inhibits ET-1-induced contraction of human pulmonary and radial arteries in vitro (Kd = 0.042 and 0.11 μM, respectively). In a rat model of neonatal hyperoxic lung injury, ambrisentan (20 mg/kg per day, s.c.) reduces pulmonary arterial hypertension (PAH) as well as decreases PAH-induced right ventricular hypertrophy (RVH) and peak RV pressure. Formulations containing ambrisentan have been used in the treatment of PAH.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
αS-[(4,6-
CAS Number
177036-94-1
Molecular Formula
C22H22N2O4
Formula Weight
378.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: 30 mg/ml
- Ethanol: slightly soluble
- Methanol: slightly soluble
SMILES
CC1=NC(O[C@H](C(O)=O)C(OC)(C2=CC=CC=C2)C3=CC=CC=C3)=NC(C)=C1
InChi Code
InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1
InChi Key
OUJTZYPIHDYQMC-LJQANCHMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10496-5 |
|---|---|
| Supplier Part Number | 10496-5 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/10496m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 5 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | Y |
| CAS Number | 4478-93-7 |