Cayman Unc669; Purity- Greater Than Or Equal To 98%; Size- 10 Mg

CP 809,101 is a potent agonist of the serotonin (5-HT) receptor subtype 5-HT_2C. It is selective for human 5-HT_2C and rat 5-HT_2C over human 5-HT_2A, 5-HT_2B, and rat 5-HT_2A receptors in a FLIPR membrane potential assay (EC₅₀s = 0.11, 0.06, 153, 65.3, and 119 nM, respectively) as well as human dopamine D₂, histamine H₁, and α₁- and α₂-adrenergic receptors (K_is = 872, 828, 217, and 956 nM, respectively). CP 809,101 inhibits the conditioned avoidance response, hyperactivity induced by PCP and D-amphetamine, and spontaneous locomotor activity in rats (ED₅₀s = 4.8, 2.4, 2.9, and 2 mg/kg, respectively). It reduces prepulse inhibition deficits induced by apomorphine and improves novel object recognition in mice. CP 809,101 (0.01-1 μg/0.2 μl/side) reduces reinstatement of drug-seeking behavior in cocaine-primed rats when administered into the central amygdala but not the basolateral amygdala. It also reduces reinstatement of food-seeking behavior in a rat model of dietary relapse.

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