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Cayman Sr 1001; Purity- Greater Than Or Equal To 98%; Size- 1 Mg
NETA PART: | CAYM-10922-1 |
MFG.PART: | 10922-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Retinoic-acid-receptor-related orphan receptors (ROR) α and γ play a key role in the development of T-helper cells that produce interleukin-17 (TH17 cells), a subset of CD4+ T-cells that contribute to the inflammatory process and have been implicated in the pathology of autoimmune diseases. SR 1001 is a synthetic ligand specific for RORα and RORγ (Kis = 172 and 111 nM, respectively) that functions as an inverse agonist at these receptors. SR 1001 has been shown to suppress IL-17 promoter driven transcriptional activity by inhibiting the interaction of co-activators such as TRAP220 nuclear receptor box 2 peptide (IC50 = 117 nM) and SRC2 with RORα and RORγ as well as by increasing the recruitment of corepressors such as NCoR. At 5 μM, SR 1001 inhibits TH17 cell differentiation and IL-17A secretion in cultured splenocytes and human PBMCs. A 25 mg/kg dose of SR 1001 twice/day delays the onset and the severity of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 20 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 30 mg/ml
- Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
Shipping & Storage Information
SKU | CAYM-10922-1 |
---|---|
Supplier Part Number | 10922-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10922m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1335106-03-0 |