Cayman Core Histones (Human); Purity- Greater Than Or Equal To 95

Each vial contains 200 µg of lyophilized peptide derived from the human EP₂ receptor sequence (C-terminal amino acids 335-358; SLRTQDATQTSCSTQSDASKQADL). This peptide was used as an antigen for production of the EP₂ receptor polyclonal antibody (Catalog No. ) and can be used in conjunction with this antibody to block protein-antibody complex formation during immunochemical analysis for the EP₂ receptor. The biological effects of prostaglandin E₂ (PGE₂) are mediated through interaction with four distinct membrane-bound G-protein coupled EP receptors: EP₁, EP₂, EP₃, and EP₄.^, Binding of PGE₂ to the EP₂ receptor results in an increase in adenylate cyclase activity with a subsequent increase in cAMP.^, Pharmacologically, EP₂ receptors mediate relaxation of smooth muscle and are distinguished from EP₄ receptors by their sensitivity to the EP₂ receptor selective agonist butaprost.^,, The human EP₂ receptor is comprised of 358 amino acids with a molecular mass of approximately 40,000. A band at 53 kDa is detected in most samples by western blotting. mRNA for the EP₂ receptor is expressed in a variety of tissues including lung, placenta, spleen, intestine, kidney, and sensory neuron.^,,

WARNING This product is not for human or veterinary use.