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Cayman All-Trans Retinoic Acid; Purity- Greater Than Or Equal To
NETA PART: | CAYM-11017-1 |
MFG.PART: | 11017-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARα, RARβ, and RARγ, respectively, in radioligand binding assays. It induces expression of a luciferase reporter in COS-7 cells expressing RARα, RARβ, or RARγ (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid (17 nmol) reduces papilloma formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. ) in mice. It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of α-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis. all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.
WARNING This product is not for human or veterinary use.
Technical Information
- atRA
- NSC 122578
- NSC 122758
- RA
- Vitamin A Acid
- DMF: 20 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 0.5 mg/ml
Shipping & Storage Information
SKU | CAYM-11017-1 |
---|---|
Supplier Part Number | 11017-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11017m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 302-79-4 |