We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman All-Trans Retinoic Acid; Purity- Greater Than Or Equal To
NETA PART: | CAYM-11017-5 |
MFG.PART: | 11017-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Eliglustat is an inhibitor of glucosylceramide synthase (IC50 = 40 nM for inhibition of glucosylceramide production in K562 cells). It is selective for glucosylceramide synthase over α-glucosidase I and II, α-1,6-glucosidase, lysosomal glucocerebrosidase, non-lysosomal glucosylceramidase, sucrase, and maltase (IC50s = >10 µM for all). It decreases cell surface levels of the gangliosides GM1 and GM3 in K562 and B16/F10 cells with IC50 values of 24 and 29 nM, respectively. Eliglustat (150 mg/kg per day) decreases glucosylceramide levels in the liver and lungs of D409V/null mice, a model of Gaucher disease. Formulations containing eliglustat have been used in the treatment of type 1 Gaucher disease.
WARNING This product is not for human or veterinary use.
Technical Information
- Genz-112638
- DMF: 20 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 20 mg/ml
- Ethanol:PBS (pH 7.2) (1:30): 0.03 mg/ml
Shipping & Storage Information
SKU | CAYM-11017-5 |
---|---|
Supplier Part Number | 11017-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11017m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 302-79-4 |