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Cayman Sb-366791; Purity- Greater Than Or Equal To 98%; Size- 50
Cayman Sb-366791; Purity- Greater Than Or Equal To 98%; Size- 50 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$457.00
Your Price
$457.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-11019-50 |
| MFG.PART: | 11019-50 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
The transient receptor potential vanilloid type 1 (TRPV1) receptor is a nonselective cation channel gated by noxious heat, protons, and capsaicin. TRPV1 is present in primary sensory neurons and in both central and peripheral sensory nerve terminals and plays a role in thermal and mechanical hyperalgesia. SB-366791 is a selective TRPV1 antagonist that is widely used in pain research.1 In cultured trigeminal ganglion neurons, SB-366791 inhibits capsaicin-evoked Ca2+ influx with an IC50 value of 0.7 μM.1 A 1 nmol injection of SB-366791 in mouse paw reduces capsaicin-induced nociceptive responses in a model of pain.2 Intrathecal pretreatment of 10 μl SB-366791 in rats suppresses tolerance to the analgesic effects of chronic morphine administration.3 Co-administration of morphine and SB-366791 at 0.1 mg/kg has potent analgesic effects in a mouse model of bone cancer pain.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-(4-
CAS Number
472981-92-3
Molecular Formula
C16H14ClNO2
Formula Weight
287.7
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/ml
- DMF:PBS (pH 7.2) (1:5): 0.15 mg/ml
- DMSO: 10 mg/ml
λmax
297 nm
SMILES
ClC1=CC=C(/C=C/C(NC2=CC(OC)=CC=C2)=O)C=C1
InChi Code
InChI=1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+
InChi Key
RYAMDQKWNKKFHD-JXMROGBWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-11019-50 |
|---|---|
| Supplier Part Number | 11019-50 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/11019m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 50 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 472981-92-3 |