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Cayman 25-Hydroxy Cholesterol; Purity- Greater Than Or Equal To 9
NETA PART: | CAYM-11097-100 |
MFG.PART: | 11097-100 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
25-hydroxy Cholesterol is an oxysterol.1 It is formed from cholesterol by cholesterol-25-hydroxylase, and its production can be induced by inflammation or infection.2 25-hydroxy Cholesterol suppresses endogenous cholesterol synthesis by binding to insulin-induced gene (INSIG) proteins and preventing sterol regulatory element binding proteins (SREBPs) from being transported to the Golgi. It inhibits IgA class switching induced by LPS and various cytokines in B cells (IC50 = ~50 nM).3 25-hydroxy Cholesterol inhibits replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50 = 3.675 µM) and reduces increases in viral protein production in infected Vero cells when used prior to infection.4 It reduces viral RNA loads in the lung and trachea in a mouse model of SARS-CoV-2 infection when administered at a dose of 100 mg/kg per day. Serum levels of 25-hydroxy cholesterol are increased in mice expressing human angiotensin-converting enzyme 2 (hACE2), the functional receptor for SARS-CoV-2, in a model of SARS-CoV-2 infection and in a patient with COVID-19, the primarily respiratory disease caused by SARS-CoV-2.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 1 mg/ml
- DMSO: 0.1 mg/ml
- Ethanol: 20 mg/ml
- Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
Shipping & Storage Information
SKU | CAYM-11097-100 |
---|---|
Supplier Part Number | 11097-100 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11097m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 100 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 2140-46-7 |