Cayman Indole-3-Carbinol; Purity- Greater Than Or Equal To 98%; S

Procyanidin B3 is a polyphenol flavonoid dimer of (+)-catechin (Item No. ) that has been found in G. biloba and has diverse biological activities.^,, It inhibits aggregation of amyloid-β (1-42) (Aβ42; Item No. ) with an IC₅₀ value of 3.54 μM and destabilizes preformed Aβ42 fibrils (EC₅₀ = 5.12 μM). Procyanidin B3 (1 mM) reduces oxidation of linoleic acid and scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. ) free radicals in cell-free assays. It inhibits hydrogen peroxide-induced production of inducible nitric oxide synthase (iNOS) and apoptosis in primary murine chondrocytes. Procyanidin B3 (0.01 mg/kg) reduces chondrocyte apoptosis, pseudocapsule thickness, and the frequency of ectopic cartilage formation in a mouse model of surgically induced osteoarthritis.

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