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Cayman Bay 61-3606 (Hydrochloride); Purity- Greater Than Or Equal
NETA PART: | CAYM-11423-1 |
MFG.PART: | 11423-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
BAY 61-3606 is an inhibitor of spleen tyrosine kinase (Syk; Ki = 7.5 nM). It is selective for Syk over Lyn, Fyn, Src, Itk, and BTK (Kis = >4.7 µM for all). BAY 61-3606 inhibits anti-IgE-induced histamine release in isolated human mast cells sensitized with IgE (IC50 = 5.1 nM), as well as reduces anti-IgM-induced proliferation of isolated mouse splenic B cells (IC50 = 58 nM). It sensitizes MCF-7 human breast cancer cells to apoptosis induced by TNF-related apoptosis-inducing ligand (TRAIL) when used at concentrations ranging from 0.31 to 2.5 µM. BAY 61-3606 inhibits passive cutaneous anaphylaxis in rats (ED50 = 8 mg/kg). It reduces tumor growth in an MCF-7 mouse xenograft model when administered at a dose of 50 mg/kg alone or in combination with TRAIL.
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: 10 mg/ml
Shipping & Storage Information
SKU | CAYM-11423-1 |
---|---|
Supplier Part Number | 11423-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11423m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1615197-10-8 |