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Cayman Neosolaniol; Purity- Greater Than Or Equal To 98%; Size- 5
Cayman Neosolaniol; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$667.00
Your Price
$667.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-11436-5 |
MFG.PART: | 11436-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
ONC212 is an agonist of the orphan G protein-coupled receptor GPR132 (EC50 = ~400 nM in a PathHunter® β-arrestin assay). It inhibits cell growth in a panel of 62 human leukemia cell lines, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), and hairy cell leukemias, with GI50 values ranging from less than 78 to 456 nM. ONC212 also reduces cell growth in a panel of 58 lymphoma cell lines (GI50s = <78-261 nM). In vivo, ONC212 (50 mg/kg) reduces tumor volume in HT-29 and HCT116 mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2,4,6,7,8,9- hexahydro-7- (phenylmethyl)- 4-[[4-(tri fluoromethyl) phenyl]methyl]- imidazo[1,2-a] pyrido[3,4- e]pyrimidin- 5(1H)-one
CAS Number
1807861-48-8
Molecular Formula
C24H23F3N4O
Formula Weight
440.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 1 mg/ml
- DMSO: 1 mg/ml
- DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
232 nm
SMILES
O=C(N(CC1=CC=C(C(F)(F)F)C=C1)C2=NCCN23)C4=C3CCN(C4)CC5=CC=CC=C5
InChi Code
InChI=1S/C24H23F3N4O/c25-24(26,27)19-8-6-18(7-9-19)15-31-22(32)20-16-29(14-17-4-2-1-3-5-17)12-10-21(20)30-13-11-28-23(30)31/h1-9H,10-16H2
InChi Key
DFULPGUTXZTYKA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-11436-5 |
---|---|
Supplier Part Number | 11436-5 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11436m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | IL |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 36519-25-2 |