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Cayman Ym-155; Purity- Greater Than Or Equal To 98%; Size- 1 Mg;
NETA PART: | CAYM-11490-1 |
MFG.PART: | 11490-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Dacarbazine is a DNA alkylating prodrug that is activated by P450 enzymes in liver microsomes. Following activation, it is converted, through a series of reactions, into a methyldiazonium cation that alkylates DNA at all phases of the cell cycle and induces apoptosis. In vitro, dacarbazine inhibits the growth of B16/F1, A-875, and SK-MEL-5 melanoma and non-cancerous WI-38 lung fibroblast and L-02 hepatocyte cell lines (IC50s = 260, 287, 380, 526, and 367 μM, respectively). Dacarbazine toxicity to 518A2 and SK-MEL-28 melanoma cell lines increases in a time-dependent manner with IC50 values of 121 and >400 μM, respectively, following a 1 hour incubation and 2.5 and 50 μM, respectively, following a 96 hour incubation. In vivo, dacarbazine (70 mg/kg, once every 2 days) decreases tumor volume by 59.1% in a B16/F1 murine melanoma model in mice. Formulations containing dacarbazine have been used in the treatment of metastatic melanoma and for Hodgkins lymphoma in combination with other antineoplastic agents.
WARNING This product is not for human or veterinary use.
Technical Information
- NCI C04717
- NSC 45388
- DMF: 0.3 mg/ml
- DMSO: 0.5 mg/ml
- Ethanol: 0.2 mg/ml
- PBS (pH 7.2): 0.1 mg/ml
Shipping & Storage Information
SKU | CAYM-11490-1 |
---|---|
Supplier Part Number | 11490-1 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11490m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 781661-94-7 |