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Cayman NVP-BKM120
NETA PART: | CAYM-11587-25 |
MFG.PART: | 11587-25 |
UNSPSC: | 12352100 |
Manufacturer: | Cayman |
Product Description
NVP-BKM120 is an orally bioavailable inhibitor of the class I PI3K isoforms p110α (IC50 = 52 nM) and p110β (IC50 = 166 nM).1 It is selective for these isoforms over the class III PI3K Vps34 (IC50 = 2,410 nM), the mammalian target of rapamycin (mTOR; IC50 = 2,866 nM), PI4Kβ (IC50 = >25,000 nM), and a variety of kinases (IC50s = >10,000 nM). NVP-BKM120 inhibits proliferation of human tumor and glioma cell lines, with p53 wild-type glioma cells being more sensitive than p53 mutant/deleted glioma cells (IC50s = 1.28 and 2.08 µM, respectively).2,3 It halts the cell cycle in the G2/M phase in both p53 wild-type and p53 mutant/deleted glioma cells, but p53 mutant/deleted cells reenter the cell cycle, progress into mitosis, and die via mitotic catastrophic cell death. NVP-BKM120 (1-5 mg/kg) crosses the blood brain barrier and selectively decreases phosphorylation of the PI3K target protein Akt.4 It increases survival in a U87 glioma mouse xenograft intracranial tumor model when administered orally at doses of 20 and 40 mg/kg once per week.2
WARNING This product is not for human or veterinary use.
Technical Information
- Buparlisib
- DMF: 12 mg/ml
- DMSO: 14 mg/ml
- Ethanol: 17 mg/ml
- Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
Shipping & Storage Information
SKU | CAYM-11587-25 |
---|---|
Supplier Part Number | 11587-25 |
UM | EA |
UNSPSC | 12352100 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11587m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 944396-07-0 |