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Cayman Azd 1152-Hqpa; Purity- Greater Than Or Equal To 98%; Size-
Cayman Azd 1152-Hqpa; Purity- Greater Than Or Equal To 98%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$93.00
Your Price
$93.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-11602-10 |
MFG.PART: | 11602-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
AZD 1152-HQPA is an inhibitor of Aurora kinase B (IC50 = 0.37 nM) that demonstrates ~3,700-fold greater selectivity for Aurora kinase B over Aurora kinase A (IC50 = 1.368 µM).1,2 It does not have activity against a panel of 50 other serine-threonine or tyrosine kinases, including FLT3, JAK2, and Abl.1,2 AZD 1152-HQPA has been shown to inhibit the proliferation of hematopoietic malignant cells (IC50s = 3-40 nM), disrupting spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis followed by apoptosis, and to inhibit tumor xenograft growth in vivo.2,3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-[[7-[3-[eth yl(2-hydroxy ethyl)amino] propoxy]-4-qu inazolinyl] amino]-N-(3- fluorophenyl) -1H-pyrazole- 3-acetamide
CAS Number
722544-51-6
Synonyms
- Barasertib-
HQPA
Molecular Formula
C26H30FN7O3
Formula Weight
507.6
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 1 mg/ml
- DMSO: 15 mg/ml
- DMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml
- Ethanol: slightly
- PBS (pH 7.2): slightly
λmax
223, 235, 324 nm
SMILES
OCCN(CC)CCCOC1=CC2=C(C(NC3=CC(CC(NC4=CC(F)=CC=C4)=O)=NN3)=NC=N2)C=C1
InChi Code
InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)
InChi Key
QYZOGCMHVIGURT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-11602-10 |
---|---|
Supplier Part Number | 11602-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11602m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 722544-51-6 |