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Cayman Isoforskolin; Purity- Greater Than Or Equal To 98%; Size-
![](https://netam2po.netascientific.info/media/skin/seal2.png)
![](https://netam2po.netascientific.info/media/skin/seal.png)
NETA PART: | CAYM-11716-1 |
MFG.PART: | 11716-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Isoforskolin is a naturally occurring diterpene originally isolated from the Indian coleus plant C. forskohlii. It demonstrates positive inotropic effects ex vivo in guinea pig atria (EC50 = 1.09 μM). In vivo, isoforskolin is antihypertensive, decreasing systolic blood pressure by 28 mmHg in spontaneously hypertensive rats when administered at 25 mg/kg per day, p.o. for 5 days. Pretreatment of rats with isoforskolin (10 mg/kg, i.p.) decreases LPS-induced lung injury by decreasing karyocyte, neutrophil count, and protein content in bronchoalveolar lavage fluid, and ameliorating LPS-induced lung morphological changes. Isoforskolin (1 mg/kg, i.p.) decreases mean arthritis index in a mouse model of Lyme arthritis induced by injection of B. burgdorferi basic membrane protein A (BmpA) into the tibiotarsal joint cavity. Isoforskolin also activates membranous mammalian adenylyl cyclase (AC) expressed in insect cells (EC50s = 0.8, 13.3, and 7.4 μM for AC1, AC2, and AC5, respectively).
WARNING This product is not for human or veterinary use.
Technical Information
- Chloroform: Soluble
- DMSO: Soluble
Shipping & Storage Information
SKU | CAYM-11716-1 |
---|---|
Supplier Part Number | 11716-1 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11716m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 64657-21-2 |