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Cayman Neoandrographolide; Purity- Greater Than Or Equal To 95%;
Cayman Neoandrographolide; Purity- Greater Than Or Equal To 95%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$278.00
Your Price
$278.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-11742-10 |
| MFG.PART: | 11742-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
AMTB is an antagonist of transient receptor potential melastatin 8 (TRPM8). It inhibits calcium influx induced by the TRPM8 agonist icilin (Item No. ) with an IC50 value of 0.58 µM. AMTB (3 mg/kg) decreases the number of volume-induced bladder contractions in a rat model of noxious bladder distension. It also decreases the visceromotor reflex response to urinary bladder distension (ID50 = 2.42 mg/kg), indicating antinociceptive activity. AMTB inhibits the sodium channel (Nav) isoforms Nav1.1-1.8 (IC50s = 2-14.8 µM) and decreases viability of MDA-MB-231 and SK-BR-3 breast cancer cells (IC50s = ~23.7 and 17.3 µM, respectively) in a TRPM8-independent manner.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(3-amino
CAS Number
926023-82-7
Molecular Formula
C23H26N2O2S • HCl
Formula Weight
431.0
Purity
≥98%
Formulation
A solid
Solubility
- DMSO: 100 mM
- Water: 100 mM
SMILES
O=C(N(CCCN)CC1=CC=CS1)C2=CC=CC=C2OCC3=CC(C)=CC=C3.Cl
InChi Code
InChI=1S/C23H26N2O2S.ClH/c1-18-7-4-8-19(15-18)17-27-22-11-3-2-10-21(22)23(26)25(13-6-12-24)16-20-9-5-14-28-20;/h2-5,7-11,14-15H,6,12-13,16-17,24H2,1H3;1H
InChi Key
UDXGBANGPYONOK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-11742-10 |
|---|---|
| Supplier Part Number | 11742-10 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/11742m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 27215-14-1 |