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Cayman Thj 018; Purity- Greater Than Or Equal To 98%; Size- 1 Mg
NETA PART: | CAYM-11962-1 |
MFG.PART: | 11962-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Akt1 and Akt2, also known as protein kinase Bα (PKBα) and PKBβ, respectively, are serine/threonine kinase belonging to the AGC kinase family and two of three Akt isoforms in mammals., Akt kinases function downstream of activated tyrosine kinases and PI3K to regulate a variety of cellular processes, including cell size, growth, proliferation, and survival, as well as genome stability, glucose metabolism, and neovascularization. They are comprised of an N-terminal pleckstrin homology (PH) domain, which binds to phosphatidylinositol-(3,4,5)-triphosphate (PIP3) and phosphatidylinositol-(3,4)-diphosphate (PIP2), a kinase domain, and a C-terminal regulatory hydrophobic motif. Akt1 and Akt2 are ubiquitously expressed and are the primary isoforms in endothelial cells and insulin-responsive tissues, respectively. Akt1E17K is an activating mutation that has been found in tumor tissue isolated from patients with breast, colorectal, or ovarian cancer. Akt2E17K mutations have been found in patients with hypoglycemia. Caymans Akt1E17K/Akt2E17K Rabbit Monoclonal Antibody (Clone RM336) can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications.
WARNING This product is not for human or veterinary use.
Technical Information
- PKBαE17K
- PKBβE17K
- (+) Akt1E17K
- (+) Akt2E17K
- (-) Wild-type Akt
Shipping & Storage Information
SKU | CAYM-11962-1 |
---|---|
Supplier Part Number | 11962-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11962m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 1364933-55-0 |