Cayman Ro 01-6128; Purity- Greater Than Or Equal To 98%; Size- 1

11-deoxy Prostaglandin E₁ (11-deoxy PGE₁) is a synthetic analog of PGE₁. Early reports show that it is a selective agonist for the EP₂ receptor but effective at much higher concentrations than PGE₂.^, However, later studies show that it is a non-selective agonist of EP receptors and stimulates cAMP release in Jurkat cells with an EC₅₀ of 0.25 µM. 11-deoxy PGE₁ also exhibits vasodepressor and bronchodilator responses in guinea pigs. 11-deoxy PGE₁ exhibits selectively for the mouse EP₃ receptor and is essentially equipotent to PGE₁ at this receptor subtype. The K_i values for binding to the mouse EP₁, EP₂, EP₃, and EP₄ receptors are 600, 45, 1.1, and 23 nM, respectively.

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