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Cayman Jnj-10181457 (Hydrochloride); Purity- Greater Than Or Equa
NETA PART: | CAYM-11997-1 |
MFG.PART: | 11997-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
JNJ-10181457 is an antagonist of histamine H3 receptors (Kis = 1.17 and 7.08 nM for human and rat receptors, respectively). It increases extracellular norepinephrine and acetylcholine levels in the frontal cortex of rats when administered subcutaneously at a dose of 10 mg/kg. JNJ-10181457 (1.25-10 mg/kg, p.o.) reduces the number of cataplectic attacks and time spent in cataplexy in familial narcoleptic Dobermans. In mice, JNJ-10181457 (10 mg/kg) decreases the time spent in the open areas of the elevated zero maze, as well as increases locomotor activity in an open field test. It also inhibits LPS-induced increases in time spent immobile in the tail suspension test in mice.
WARNING This product is not for human or veterinary use.
Technical Information
- RWJ 662733
- DMSO: soluble
- Water: soluble
Shipping & Storage Information
SKU | CAYM-11997-1 |
---|---|
Supplier Part Number | 11997-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11997m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 544707-20-2 |