Cayman Tandutinib; Purity- Greater Than Or Equal To 95%; Size- 25

Cayman Tandutinib; Purity- Greater Than Or Equal To 95%; Size- 250 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)

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NETA PART:	CAYM-12098-250
MFG.PART:	12098-250
UNSPSC:	12352200
Manufacturer:	Cayman

Description

Product Description

Tandutinib is a potent antagonist of platelet-derived growth factor receptor β (PDGFRβ), FLT3, and c-Kit (IC₅₀ = 200, 220, and 170 nM, respectively).¹ It less potently inhibits macrophage colony-stimulating factor 1 receptor (IC₅₀ = 3.4 µM) and does not significantly inhibit other tyrosine or serine/threonine kinases.^1,2 Tandutinib blocks the growth of cells expressing an internal tandem duplication within the juxtamembrane domain of the FLT3 receptor, found in some acute myelogenous leukemia cells.^1,3 It also impairs the growth of colon cancer cells through its actions on the c-Kit receptor.⁴ Tandutinib reverses multidrug resistance in vitro by impairing the efflux activity of the multidrug resistance protein 7.⁵

WARNING This product is not for human or veterinary use.

Technical Information

Formal Name	4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide
CAS Number	387867-13-2
Synonyms	CT 53518 MLN518
Molecular Formula	C31H42N6O4
Formula Weight	562.7
Purity	≥95%
Formulation(Request formulation change)	A crystalline solid
Solubility(Learn about Variance in Solubility)	DMF: 15 mg/ml DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml DMSO: 10 mg/ml Ethanol: 10 mg/ml
λmax	247, 332 nm
SMILES	O=C(NC1=CC=C(OC(C)C)C=C1)N(CC2)CCN2C3=NC=NC4=C3C=C(OC)C(OCCCN5CCCCC5)=C4
InChi Code	InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)
InChi Key	UXXQOJXBIDBUAC-UHFFFAOYSA-N
Storage	-20°C
Shipping	Room Temperature in continental US; may vary elsewhere
Stability	≥ 4 years

Specifications

More Information
SKU	CAYM-12098-250
Supplier Part Number	12098-250
UM	UNIT
UNSPSC	12352200
Manufacturer	Cayman
MSDS URL	https://www.caymanchem.com/msdss/12098m.pdf
Temperature	-20
Refrigerated-Frozen	Refrigerated
CountryOfOrigin	US
ProductLine	CAYM
Qty	250
MinOrderQty	1
Weight	7.00
Lead Time	2 Business Days
Hazardous	N
CAS Number	387867-13-2

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Cayman Tandutinib; Purity- Greater Than Or Equal To 95%; Size- 25

Product Description

Technical Information

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