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Cayman 2-Methyl Benzamideoxime; Purity- Greater Than Or Equal To
Cayman 2-Methyl Benzamideoxime; Purity- Greater Than Or Equal To 98%; Size- 5 G; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$234.00
Your Price
$234.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-13002-5000 |
| MFG.PART: | 13002-5000 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
INH1 is an inhibitor of the interaction between the oncogene high expression in cancer 1 (Hec1) and its regulator, the serine/threonine kinase Nek2. It binds to Hec1 and reduces Nek2 protein levels in HeLa cells when used at a concentration of 25 µM. INH1 inhibits the growth of MDA-MB-468, SK-BR-3, T47D, MDA-MB-361, ZR-75-1, HBL-100, MDA-MB-435, and Hs 578T breast cancer cells (GI50s = 10.5-20.5 µM). It inhibits migration of MDA-MB-231 cells in a transwell migration assay (IC50 = 176 nM). INH1 (50 and 100 mg/kg) reduces tumor growth in an MDA-MB-468 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[4-(2,4-
CAS Number
313553-47-8
Synonyms
- IBT 13131
Molecular Formula
C18H16N2OS
Formula Weight
308.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
- Ethanol: 10 mg/ml
λmax
235 nm
SMILES
O=C(C1=CC=CC=C1)NC2=NC(C3=CC=C(C)C=C3C)=CS2
InChi Code
InChI=1S/C18H16N2OS/c1-12-8-9-15(13(2)10-12)16-11-22-18(19-16)20-17(21)14-6-4-3-5-7-14/h3-11H,1-2H3,(H,19,20,21)
InChi Key
JPMOKRWIYQGMJL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13002-5000 |
|---|---|
| Supplier Part Number | 13002-5000 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/13002m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 5000 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | Y |
| CAS Number | 40312-14-9 |