Cayman 3-Methyl-2-Quinoxalinone; Purity- Greater Than Or Equal To

SMER28 is a small-molecule enhancer (SMER) of autophagy that increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntingtons, Parkinsons, and Alzheimers diseases.^,, SMER28 induces clearance of amyloid-β (Aβ) peptides and the amyloid precursor protein c-terminal fragment (APP-CTF) in mouse embryonic fibroblasts (MEFs) isolated from wild-type, but not autophagy-related protein 5 knockout (Atg5^-/-), mouse embryos in a concentration-dependent manner. It induces autophagy independently of rapamycin (Item No. ) in mammalian cells at a concentration of 47 µM. SMER28 also promotes reprogramming of fibroblasts into neural stem cells when used in combination with other chemical reagents.

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