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Cayman Cisplatin; Purity- Greater Than Or Equal To 95%; Size- 100
NETA PART: | CAYM-13119-100 |
MFG.PART: | 13119-100 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Cisplatin is a platinum-containing compound that acts as a DNA-crosslinking agent and interferes with replication and transcription, culminating in apoptosis. It forms intra- and interstrand crosslinks with DNA with intrastrand guanine-to-guanine or guanine-to-alanine links accounting for the majority of DNA binding. Cisplatin halts the cell cycle at the G2/M phase in vitro and is active against murine tumors transplanted into mice and in mouse xenograft models, including a reduction in tumor growth in a model of squamous cell carcinoma of the head and neck when administered at doses ranging from 7.5 to 12.5 mg/kg., Cisplatin also inhibits the RecA recombinase of M. tuberculosis (IC50 = 2 µM), blocking protein splicing and cell growth. Formulations containing cisplatin have been used, alone and in combination therapy, in the treatment of a variety of cancers.
WARNING This product is not for human or veterinary use.
Technical Information
- CDDP
- cis-
Diamminedichloroplatinum - Cisplatinum
- NSC 119875
- DMF: 10 mg/ml
- DMSO: 20 mg/ml**
- PBS (pH 7.2): 1 mg/ml (with warming)
- Water: 1 mg/ml (with warming)
Shipping & Storage Information
SKU | CAYM-13119-100 |
---|---|
Supplier Part Number | 13119-100 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/13119m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 100 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 15663-27-1 |