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Cayman Daz-1; Purity- Greater Than Or Equal To 98%; Size- 5 Mg
NETA PART: | CAYM-13173-5 |
MFG.PART: | 13173-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
U-0126 is a MEK inhibitor with IC50 values of 72 nM and 58 nM for MEK1 and MEK2, respectively. It is noncompetitive with respect adenosine triphosphate (ATP) and its phosphorylation target ERK and it shows little to no inhibition against a number of other kinases including PKC, Ab1, Raf, MEKK, ERK, JNK, MKK-3, MKK-4, MKK-6, Cdk2, and Cdk4. However, U-0126 does phosphorylate and activate AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 15 µM in HEK293 cells). It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 30 mg/ml
- DMF: PBS (pH 7.2)(1:2): 0.3 mg/ml
- DMSO: 25 mg/ml
- Ethanol: 0.5 mg/ml
Shipping & Storage Information
SKU | CAYM-13173-5 |
---|---|
Supplier Part Number | 13173-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/13173m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1112977-84-0 |