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Cayman (В±)-Blebbistatin; Purity- Greater Than Or Equal To 98%; S
NETA PART: | CAYM-13186-25 |
MFG.PART: | 13186-25 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Histone H3K27Me3 (21-44)-K-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and H3.2 sequences. It is trimethylated at lysine 27 and biotinylated via a C-terminal lysine linker. Trimethylation of histone H3 at lysine 27 is associated with gene silencing. It is involved in tumor progression through its regulation by enhancer of zeste homolog 2 (EZH2) and transcriptional repression of tumor suppressor genes., Levels of H3K27Me3 are reduced in 293 T-REx cells containing EEDR236T and SUZ12G610V mutations and in lymphoblastoid cells isolated from patients with Weaver syndrome, a rare overgrowth disorder characterized by EZH2, EED, or SUZ12 mutations, cancer susceptibility, and various distinctive physical features.
WARNING This product is not for human or veterinary use.
Technical Information
- ATKAAR-K(Me3)-SAPATGGVKKPHRYRPG-K(Biotin)
- H3(21-44)K27me3 Substrate
- Histone H3 (21-44) (Lys27me3)
- [Lys(Me3)27]-Histone H3 (21-44)-K(Biotin)
- Water: 1 mg/ml
Shipping & Storage Information
SKU | CAYM-13186-25 |
---|---|
Supplier Part Number | 13186-25 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/13186m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 25 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 674289-55-5 |