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Cayman Trandolapril; Purity- Greater Than Or Equal To 98%; Size-
NETA PART: | CAYM-13522-250 |
MFG.PART: | 13522-250 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Trandolapril is a prodrug form of the angiotensin-converting enzyme (ACE) inhibitor trandolaprilat (Item No. 29577).1 Trandolapril is converted to trandolaprilat by carboxylesterase 1 (CES1) in human liver microsomes. It inhibits angiotensin I-induced pressor responses in rats and dogs (ID50s = 13.1 and 21.1 μg/kg, respectively) and potentiates the bradykinin-induced depressor response in rats (ED50 = 5.5 μg/kg).2 Trandolapril (0.1, 0.3, and 1 mg/kg) decreases systolic and diastolic arterial pressure in dogs. It decreases mean arterial pressure (MAP) and left ventricular end-diastolic pressure (LVEDP) in a rat model of heart failure induced by left coronary artery occlusion when administered at a dose of 3 mg/kg.3 Trandolapril (0.01 and 1 mg/kg) increases survival in stroke-prone spontaneously hypertensive rats fed a high-salt diet.4 Formulations containing trandolapril have been used in the treatment of hypertension.
WARNING This product is not for human or veterinary use.
Technical Information
- RU-44570
- DMF: 15 mg/ml
- DMSO: 25 mg/ml
- Ethanol: 0.25 mg/ml
- PBS (pH 7.2): 1 mg/ml
Shipping & Storage Information
SKU | CAYM-13522-250 |
---|---|
Supplier Part Number | 13522-250 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/13522m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 250 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 87679-37-6 |