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Cayman Apelin-36; Purity- Greater Than Or Equal To 95%; Size- 5 M
NETA PART: | CAYM-13524-5 |
MFG.PART: | 13524-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
TAS 115 is a multi-kinase inhibitor that inhibits the growth factor receptors PDGFRα and PDGFRβ (IC50s = 0.81 and 7.06 nM, respectively), c-FMS (IC50 = 15 nM), VEGFR2 and VEGFR1 (IC50s = 30 and 140 nM, respectively), Met (IC50 = 32 nM), and FGFR2 (IC50 = 340 nM)., It also inhibits Axl, c-Kit, Src, and FLT1. TAS 115 inhibits VEGF-induced VEGFR2 phosphorylation in human umbilical vein endothelial cells (HUVECs) and Met phosphorylation in Met-amplified MKN45 human gastric cancer cells. It also inhibits VEGF-dependent, but not VEGF-independent, growth of HUVECs (IC50s = 0.019 and 19.3 µM, respectively) and of Met-amplified MKN45, but not Met-inactivated, human MCF-7 breast cancer cells (GI50s = 0.032 and >10 µM, respectively). TAS 115 reduces tumor growth in a MKN45 mouse xenograft model (ED50 = 8 mg/kg).
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: slightly soluble
- PBS (pH 7.2): slightly soluble
- Water: slightly soluble
Shipping & Storage Information
SKU | CAYM-13524-5 |
---|---|
Supplier Part Number | 13524-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/13524m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 252642-12-9 |